Hydroxyurea 500mg tablet vs 500mg capsule what are the differences?

Hydroxyurea is available in both tablet and capsule forms, but the differences between them mainly lie in their formulation, ease of use, and potential additives. Here’s a comparison in table form:

AspectHydroxyurea 500mg TabletHydroxyurea 500mg Capsule
FormulationSolid, compressed powderPowder or liquid encased in a gelatin shell
AbsorptionSimilar absorption rateSimilar absorption rate
Ease of SwallowingMay be harder to swallow for some individualsTypically easier to swallow due to smooth surface
Splitting/DosingCan be split in some cases (if scored)Cannot be split or opened, must be swallowed whole
TasteBitter, can be unpleasantLess likely to cause taste issues due to the gelatin shell
AdditivesMay contain different inactive ingredientsUsually contains gelatin and other capsule fillers
StabilityGenerally stable at room temperatureGenerally stable, but capsules may be sensitive to moisture
StorageRequires dry, room temperature storageRequires similar storage, but capsules may degrade faster if exposed to moisture

Important Note:

  • Always consult with your healthcare provider to determine the most appropriate form of hydroxyurea for your specific condition and needs.
  • Do not switch between tablet and capsule forms without consulting your doctor, as it may affect the dosing or efficacy of the medication.

Sources used:

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