Morphine Sulfate 15 mg er Vs Xtampza 18mg

Morphine Sulfate and Xtampza are both extended-release opioid medications used to manage moderate to severe chronic pain. However, they differ in their active ingredients and formulations.

Key Differences:

  • Active Ingredient:
    • Morphine Sulfate: Contains morphine, a natural opioid.
    • Xtampza: Contains oxycodone, a semi-synthetic opioid.
  • Formulation:
    • Morphine Sulfate: Typically comes in tablet form.
    • Xtampza: Comes in capsule form.
  • Abuse-Deterrent Properties:
    • Xtampza: Has abuse-deterrent properties designed to make it more difficult to crush or manipulate, reducing the risk of overdose or misuse.

Here’s a detailed comparison chart of Morphine Sulfate 15 mg ER vs Xtampza ER 18 mg:

AspectMorphine Sulfate 15 mg ERXtampza ER 18 mg
Active IngredientMorphine sulfateOxycodone (in abuse-deterrent Xtampza formulation)
Strength/ Dose15 mg18 mg
Drug ClassOpioid analgesicOpioid analgesic
Mechanism of ActionBinds to opioid receptors, reducing pain signalsBinds to opioid receptors, but more potent than morphine
Extended-ReleaseYes (ER – Extended Release)Yes (ER – Extended Release)
Duration of ActionTypically 8-12 hoursTypically 12 hours
PotencyLess potent per milligram compared to oxycodoneMore potent per milligram than morphine
Common UsesSevere chronic painSevere chronic pain
Abuse-Deterrent FormulationNoYes, Xtampza ER is formulated to resist misuse (crushing, snorting)
Onset of Action30-60 minutes30-60 minutes
PharmacokineticsPeak levels in about 3-4 hoursPeak levels in about 3-4 hours
Bioavailability20-30% (oral)About 60-87% (due to specialized formulation allowing for higher absorption when taken with food)
Food InteractionMinimalMust be taken with food for optimal absorption
Common Side EffectsDrowsiness, constipation, nausea, dizzinessDrowsiness, constipation, nausea, dizziness
Risk of Tolerance/DependenceHighHigh
Withdrawal SymptomsYes (if abruptly discontinued after long-term use)Yes (if abruptly discontinued after long-term use)
Regulatory StatusSchedule II Controlled SubstanceSchedule II Controlled Substance
Brand/Generic AvailabilityGeneric availableBrand only (Xtampza ER)
CostTypically lower (generic available)Typically higher (brand name with special formulation)

It’s crucial to consult with your healthcare provider to determine the most appropriate medication for your individual circumstances. They can assess your medical history, pain management needs, and potential side effects to make an informed decision.

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